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Loss of Spry1 reduces growth of BRAF(V600)-mutant cutaneous melanoma and improves response to targeted therapy
Mitogen-activated protein kinase (MAPK) pathway activation is a central step in BRAF(V600)-mutant cutaneous melanoma (CM) pathogenesis. In the last years, Spry1 has been frequently described as an upstream regulator of MAPK signaling pathway. However, its specific role in BRAF(V600)-mutant CM is sti...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244546/ https://www.ncbi.nlm.nih.gov/pubmed/32444628 http://dx.doi.org/10.1038/s41419-020-2585-y |