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Dietary sodium modulates nephropathy in Nedd4-2-deficient mice
Salt homeostasis is maintained by tight control of Na(+) filtration and reabsorption. In the distal part of the nephron the ubiquitin protein ligase Nedd4-2 regulates membrane abundance and thus activity of the epithelial Na(+) channel (ENaC), which is rate-limiting for Na(+) reabsorption. Nedd4-2 d...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244563/ https://www.ncbi.nlm.nih.gov/pubmed/31802037 http://dx.doi.org/10.1038/s41418-019-0468-5 |