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Dietary sodium modulates nephropathy in Nedd4-2-deficient mice

Salt homeostasis is maintained by tight control of Na(+) filtration and reabsorption. In the distal part of the nephron the ubiquitin protein ligase Nedd4-2 regulates membrane abundance and thus activity of the epithelial Na(+) channel (ENaC), which is rate-limiting for Na(+) reabsorption. Nedd4-2 d...

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Detalles Bibliográficos
Autores principales: Manning, Jantina A., Shah, Sonia S., Henshall, Tanya L., Nikolic, Andrej, Finnie, John, Kumar, Sharad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244563/
https://www.ncbi.nlm.nih.gov/pubmed/31802037
http://dx.doi.org/10.1038/s41418-019-0468-5