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Dietary sodium modulates nephropathy in Nedd4-2-deficient mice

Salt homeostasis is maintained by tight control of Na(+) filtration and reabsorption. In the distal part of the nephron the ubiquitin protein ligase Nedd4-2 regulates membrane abundance and thus activity of the epithelial Na(+) channel (ENaC), which is rate-limiting for Na(+) reabsorption. Nedd4-2 d...

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Detalles Bibliográficos
Autores principales:	Manning, Jantina A., Shah, Sonia S., Henshall, Tanya L., Nikolic, Andrej, Finnie, John, Kumar, Sharad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244563/ https://www.ncbi.nlm.nih.gov/pubmed/31802037 http://dx.doi.org/10.1038/s41418-019-0468-5

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