Nuclear Parkin Activates the ERRα Transcriptional Program and Drives Widespread Changes in Gene Expression Following Hypoxia

Parkin is an E3 ubiquitin ligase well-known for facilitating clearance of damaged mitochondria by ubiquitinating proteins on the outer mitochondrial membrane. However, knowledge of Parkin’s functions beyond mitophagy is still limited. Here, we demonstrate that Parkin has functions in the nucleus and...

Descripción completa

Detalles Bibliográficos
Autores principales: Shires, Sarah E., Quiles, Justin M., Najor, Rita H., Leon, Leonardo J., Cortez, Melissa Q., Lampert, Mark A., Mark, Adam, Gustafsson, Åsa B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244578/
https://www.ncbi.nlm.nih.gov/pubmed/32444656
http://dx.doi.org/10.1038/s41598-020-65438-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244578/
https://www.ncbi.nlm.nih.gov/pubmed/32444656
http://dx.doi.org/10.1038/s41598-020-65438-7

Ejemplares similares