PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment

A rare coding variant (rs72824905, p.P522R) conferring protection against Alzheimer’s disease (AD) was identified in the gene encoding the enzyme phospholipase-C-γ2 (PLCG2) that is highly expressed in microglia. To explore the protective nature of this variant, we employed latent process linear mixe...

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Detalles Bibliográficos
Autores principales: Kleineidam, Luca, Chouraki, Vincent, Próchnicki, Tomasz, van der Lee, Sven J., Madrid-Márquez, Laura, Wagner-Thelen, Holger, Karaca, Ilker, Weinhold, Leonie, Wolfsgruber, Steffen, Boland, Anne, Martino Adami, Pamela V., Lewczuk, Piotr, Popp, Julius, Brosseron, Frederic, Jansen, Iris E., Hulsman, Marc, Kornhuber, Johannes, Peters, Oliver, Berr, Claudine, Heun, Reinhard, Frölich, Lutz, Tzourio, Christophe, Dartigues, Jean-François, Hüll, Michael, Espinosa, Ana, Hernández, Isabel, de Rojas, Itziar, Orellana, Adelina, Valero, Sergi, Stringa, Najada, van Schoor, Natasja M., Huisman, Martijn, Scheltens, Philip, Rüther, Eckart, Deleuze, Jean-Francois, Wiltfang, Jens, Tarraga, Lluis, Schmid, Matthias, Scherer, Martin, Riedel-Heller, Steffi, Heneka, Michael T., Amouyel, Philippe, Jessen, Frank, Boada, Merce, Maier, Wolfgang, Schneider, Anja, González-Pérez, Antonio, van der Flier, Wiesje M., Wagner, Michael, Lambert, Jean-Charles, Holstege, Henne, Sáez, Mª Eugenia, Latz, Eicke, Ruiz, Agustin, Ramirez, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244617/
https://www.ncbi.nlm.nih.gov/pubmed/32166339
http://dx.doi.org/10.1007/s00401-020-02138-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244617/
https://www.ncbi.nlm.nih.gov/pubmed/32166339
http://dx.doi.org/10.1007/s00401-020-02138-6

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