Methylation of a CGATA element inhibits binding and regulation by GATA-1

Alterations in DNA methylation occur during development, but the mechanisms by which they influence gene expression remain uncertain. There are few examples where modification of a single CpG dinucleotide directly affects transcription factor binding and regulation of a target gene in vivo. Here, we...

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Detalles Bibliográficos
Autores principales: Yang, Lu, Chen, Zhiliang, Stout, Elizabeth S., Delerue, Fabien, Ittner, Lars M., Wilkins, Marc R., Quinlan, Kate G. R., Crossley, Merlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244756/
https://www.ncbi.nlm.nih.gov/pubmed/32444652
http://dx.doi.org/10.1038/s41467-020-16388-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244756/
https://www.ncbi.nlm.nih.gov/pubmed/32444652
http://dx.doi.org/10.1038/s41467-020-16388-1

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