Cargando…

Klotho Alleviates Lung Injury Caused by Paraquat via Suppressing ROS/P38 MAPK-Regulated Inflammatory Responses and Apoptosis

Acute lung injury (ALI) induced by paraquat (PQ) progresses rapidly with high mortality; however, there is no effective treatment, and the specific mechanism is not well understood. The antiaging protein klotho (KL) has multiple functions and exerts significant influences on various pathophysiologic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Zhiqiang, Nian, Qing, Chen, Gang, Cui, Shuqing, Han, Yuzhen, Zhang, Jinying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244968/ https://www.ncbi.nlm.nih.gov/pubmed/32509139 http://dx.doi.org/10.1155/2020/1854206

Ejemplares similares

Klotho Improves Cardiac Function by Suppressing Reactive Oxygen Species (ROS) Mediated Apoptosis by Modulating Mapks/Nrf2 Signaling in Doxorubicin-Induced Cardiotoxicity
por: Zhu, Huolan, et al.
Publicado: (2017)

Nonthermal Plasma Induces Apoptosis in ATC Cells: Involvement of JNK and p38 MAPK-Dependent ROS
por: Lee, Sei Young, et al.
Publicado: (2014)

Role of the MAPK pathway in human lung epithelial-like A549 cells apoptosis induced by paraquat
por: Sun, Da-Zhuang, et al.
Publicado: (2020)

Cilostazol alleviate nicotine induced cardiomyocytes hypertrophy through modulation of autophagy by CTSB/ROS/p38MAPK/JNK feedback loop
por: Wang, Shu-ya, et al.
Publicado: (2020)

Infiltrating macrophages in diabetic nephropathy promote podocytes apoptosis via TNF-α-ROS-p38MAPK pathway
por: Guo, Yinfeng, et al.
Publicado: (2017)

Protective effect of Xuebijing injection on paraquat-induced pulmonary injury via down-regulating the expression of p38 MAPK in rats
por: Liu, Ming-wei, et al.
Publicado: (2014)

Curcumin Induces Apoptosis of Chemoresistant Lung Cancer Cells via ROS-Regulated p38 MAPK Phosphorylation
por: Wu, Ming-Fang, et al.
Publicado: (2022)

ROS, Klotho and mTOR in cardiorenal aging
por: Daneshgar, Nastaran, et al.
Publicado: (2020)

Dioscin facilitates ROS-induced apoptosis via the p38-MAPK/HSP27-mediated pathways in lung squamous cell carcinoma
por: Yao, Yinan, et al.
Publicado: (2020)

Saikosaponin D Attenuates Pancreatic Injury Through Suppressing the Apoptosis of Acinar Cell via Modulation of the MAPK Signaling Pathway
por: Li, Caixia, et al.
Publicado: (2021)

Lotus leaf flavonoids induce apoptosis of human lung cancer A549 cells through the ROS/p38 MAPK pathway
por: Jia, Xiang-Bo, et al.
Publicado: (2021)

Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways
por: Brobey, Reynolds K., et al.
Publicado: (2015)

Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation
por: Zhang, Xiyu, et al.
Publicado: (2015)

Nickel induces blood-testis barrier damage through ROS-mediated p38 MAPK pathways in mice
por: Zeng, Yuxin, et al.
Publicado: (2023)

MCU Inhibitor Ruthenium Red Alleviates the Osteoclastogenesis and Ovariectomized Osteoporosis via Suppressing RANKL-Induced ROS Production and NFATc1 Activation through P38 MAPK Signaling Pathway
por: Wang, Yuxin, et al.
Publicado: (2022)

High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway
por: Li, Pei, et al.
Publicado: (2017)

Klotho alleviates chronic intermittent hypoxia-induced genioglossus myocyte apoptosis by inhibiting endoplasmic reticulum stress
por: Xue, Zhen, et al.
Publicado: (2021)

Pentosan polysulfate ameliorates apoptosis and inflammation by suppressing activation of the p38 MAPK pathway in high glucose-treated HK-2 cells
por: Chen, Ping, et al.
Publicado: (2018)

MicroRNA-22 alleviates inflammation in ischemic stroke via p38 MAPK pathways
por: Dong, Huixiao, et al.
Publicado: (2019)

Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy
por: Zhang, Shuwen, et al.
Publicado: (2021)

Biochanin A Alleviates Cerebral Ischemia/Reperfusion Injury by Suppressing Endoplasmic Reticulum Stress-Induced Apoptosis and p38MAPK Signaling Pathway In Vivo and In Vitro
por: Guo, Min-min, et al.
Publicado: (2021)

Lobaplatin-Induced Apoptosis Requires p53-Mediated p38MAPK Activation Through ROS Generation in Non-Small-Cell Lung Cancer
por: Zhang, Hongming, et al.
Publicado: (2019)

Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways
por: Jiang, Zhongjia, et al.
Publicado: (2017)

Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway
por: Yang, Xiaorong, et al.
Publicado: (2018)

Parishin alleviates vascular ageing in mice by upregulation of Klotho
por: Zhao, Xinxiu, et al.
Publicado: (2023)

Cancer suppression by systemic inactivation of p38MAPK
por: Brichkina, Anna, et al.
Publicado: (2017)

Ginaton injection alleviates cisplatin-induced renal interstitial fibrosis in rats via inhibition of apoptosis through regulation of the p38MAPK/TGF-β1 and p38MAPK/HIF-1α pathways
por: Liang, Taolin, et al.
Publicado: (2021)

Maternal inflammation activated ROS-p38 MAPK predisposes offspring to heart damages caused by isoproterenol via augmenting ROS generation
por: Zhang, Qi, et al.
Publicado: (2016)

Autophagy protects bone marrow mesenchymal stem cells from palmitate-induced apoptosis through the ROS-JNK/p38 MAPK signaling pathways
por: Liu, Yongyi, et al.
Publicado: (2018)

Paraquat-Induced Reactive Oxygen Species Inhibit Neutrophil Apoptosis via a p38 MAPK/NF-κB–IL-6/TNF-α Positive-Feedback Circuit
por: Wang, Xiaolong, et al.
Publicado: (2014)

Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer
por: Xie, Biao, et al.
Publicado: (2013)

Impairment of Mitochondrial Biogenesis and Dynamics Involved in Isoniazid-Induced Apoptosis of HepG2 Cells Was Alleviated by p38 MAPK Pathway
por: Zhang, Tianguang, et al.
Publicado: (2017)

ROS-induced Oxidative Injury involved in Pathogenesis of Fungal Keratitis via p38 MAPK Activation
por: Hua, Xia, et al.
Publicado: (2017)

Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS
por: Woo, Chern Chiuh, et al.
Publicado: (2013)

Irinotecan Induces Autophagy-Dependent Apoptosis and Positively Regulates ROS-Related JNK- and P38-MAPK Pathways in Gastric Cancer Cells
por: Zhu, Qingyun, et al.
Publicado: (2020)

Podophyllotoxin Induces ROS-Mediated Apoptosis and Cell Cycle Arrest in Human Colorectal Cancer Cells via p38 MAPK Signaling
por: Lee, Seung-On, et al.
Publicado: (2021)

Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma
por: Li, Shenglan, et al.
Publicado: (2022)

Licochalcone B Induces ROS-Dependent Apoptosis in Oxaliplatin-Resistant Colorectal Cancer Cells via p38/JNK MAPK Signaling
por: Kwak, Ah-Won, et al.
Publicado: (2023)

Resveratrol and Montelukast Alleviate Paraquat-Induced Hepatic Injury in Mice: Modulation of Oxidative Stress, Inflammation, and Apoptosis
por: El-Boghdady, Noha A., et al.
Publicado: (2017)

Loganin alleviates testicular damage and germ cell apoptosis induced by AGEs upon diabetes mellitus by suppressing the RAGE/p38MAPK/NF‐κB pathway
por: Chen, Yuping, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0ubeba1job9jvf048bf01rbaj7