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Direct observation of helicase–topoisomerase coupling within reverse gyrase

Reverse gyrases (RGs) are the only topoisomerases capable of generating positive supercoils in DNA. Members of the type IA family, they do so by generating a single-strand break in substrate DNA and then manipulating the two single strands to generate positive topology. Here, we use single-molecule...

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Detalles Bibliográficos
Autores principales: Yang, Xi, Garnier, Florence, Débat, Hélène, Strick, Terence R., Nadal, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245102/
https://www.ncbi.nlm.nih.gov/pubmed/32371489
http://dx.doi.org/10.1073/pnas.1921848117