Wnt3a Inhibitor Attenuates Remifentanil-Induced Hyperalgesia via Downregulating Spinal NMDA Receptor in Rats

PURPOSE: The upregulation of spinal NMDA receptor is a crucial mechanism in remifentanil-induced hyperalgesia (RIH). Wnt3a/β-catenin pathway plays an important role in neuropathic pain. We hypothesized that wnt3a inhibitor (iwp-2) could downregulate the expression of NR(2)B subunit in NMDA receptor...

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Detalles Bibliográficos
Autores principales: Gao, Yuan, Zhou, Songyi, Pan, Yizhao, Gu, Lijun, He, Yuting, Sun, Jiehao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245459/
https://www.ncbi.nlm.nih.gov/pubmed/32547170
http://dx.doi.org/10.2147/JPR.S250663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245459/
https://www.ncbi.nlm.nih.gov/pubmed/32547170
http://dx.doi.org/10.2147/JPR.S250663

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