Lipophilic Prodrug of Methotrexate in the Membrane of Liposomes Promotes Their Uptake by Human Blood Phagocytes

Previously, we showed that incorporation of methotrexate (MTX) in the form of a lipophilic prodrug (MTXDG) in 100-nm lipid bilayer liposomes of egg phosphatidylcholine can allow one to reduce toxicity and improve the antitumor efficiency of MTX in a mouse model of T-cell leukemic lymphoma. However,...

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Detalles Bibliográficos
Autores principales: Tretiakova, D. S., Khaidukov, S. V., Babayants, A. A., Frolova, I. S., Shcheglovitova, O. N., Onishchenko, N. R., Vodovozova, E. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245962/
https://www.ncbi.nlm.nih.gov/pubmed/32477604
http://dx.doi.org/10.32607/actanaturae.10946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245962/
https://www.ncbi.nlm.nih.gov/pubmed/32477604
http://dx.doi.org/10.32607/actanaturae.10946

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