Discovery of anti-influenza nucleoside triphosphates targeting the catalytic site of A/PR/8/34/H1N1 polymerase

In an effort to develop potent anti-influenza drugs that inhibit the activity of influenza virus RNA-dependent RNA polymerase (IAV RdRp), a database of nucleoside triphosphates with ~800 molecules were docked with the homology model of IAV RdRp from A/PR/8/34/H1N1 strain. Out of top 12 molecules tha...

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Detalles Bibliográficos
Autores principales: Pagadala, Nataraj Sekhar, Bhat, Rakesh, Kumar D, Jagadeesh, Landi, Abdolamir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246003/
https://www.ncbi.nlm.nih.gov/pubmed/32837136
http://dx.doi.org/10.1007/s00044-020-02561-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246003/
https://www.ncbi.nlm.nih.gov/pubmed/32837136
http://dx.doi.org/10.1007/s00044-020-02561-0

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