Comparison of the Pharmacokinetics of Highly Variable Drugs in Healthy Subjects Using a Partial Replicated Crossover Study: A Fixed-Dose Combination of Fimasartan 120 mg and Atorvastatin 40 mg versus Separate Tablets

PURPOSE: A fixed-dose combination (FDC) of fimasartan and atorvastatin is used to treat hypertension and dyslipidemia. The peak plasma concentration (C(max)) of fimasartan and atorvastatin has a large intra-subject variability with a maximum coefficient of variation of 65% and 48%, respectively. The...

Descripción completa

Detalles Bibliográficos
Autores principales: Hwang, Jun Gi, Yu, Kyung-Sang, Lee, SeungHwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246321/
https://www.ncbi.nlm.nih.gov/pubmed/32546962
http://dx.doi.org/10.2147/DDDT.S233732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246321/
https://www.ncbi.nlm.nih.gov/pubmed/32546962
http://dx.doi.org/10.2147/DDDT.S233732

Ejemplares similares