Leukamenin E Induces K8/18 Phosphorylation and Blocks the Assembly of Keratin Filament Networks Through ERK Activation

Leukamenin E is a natural ent-kaurane diterpenoid isolated from Isodon racemosa (Hemsl) Hara that has been found to be a novel and potential keratin filament inhibitor, but its underlying mechanisms remain largely unknown. Here, we show that leukamenin E induces keratin filaments (KFs) depolymerizat...

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Detalles Bibliográficos
Autores principales: Xia, Bo, Zhang, Hui, Yang, Minghui, Du, Shilong, Wei, Jingxin, Ding, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246489/
https://www.ncbi.nlm.nih.gov/pubmed/32365802
http://dx.doi.org/10.3390/ijms21093164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246489/
https://www.ncbi.nlm.nih.gov/pubmed/32365802
http://dx.doi.org/10.3390/ijms21093164

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