Data-Driven Modeling Identifies TIRAP-Independent MyD88 Activation Complex and Myddosome Assembly Strategy in LPS/TLR4 Signaling

TLR4 complexes are essential for the initiation of the LPS-induced innate immune response. The Myddosome, which mainly contains TLR4, TIRAP, MyD88, IRAK1/4 and TRAF6 proteins, is regarded as a major complex of TLR4. Although the Myddosome has been well studied, a quantitative description of the Mydd...

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Detalles Bibliográficos
Autores principales: Li, Xiang, Zhong, Chuan-Qi, Yin, Zhiyong, Qi, Hong, Xu, Fei, He, Qingzu, Shuai, Jianwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246728/
https://www.ncbi.nlm.nih.gov/pubmed/32357531
http://dx.doi.org/10.3390/ijms21093061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246728/
https://www.ncbi.nlm.nih.gov/pubmed/32357531
http://dx.doi.org/10.3390/ijms21093061

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