Orphan Nuclear Receptor RORα Regulates Enzymatic Metabolism of Cerebral 24S-Hydroxycholesterol through CYP39A1 Intronic Response Element Activation

Oxysterols, important regulators of cholesterol homeostasis in the brain, are affected by neurodegenerative diseases. Early-onset Alzheimer’s disease is associated with higher levels of circulating brain-derived 24S-hydroxycholesterol (24S-OHC). Conversion of cholesterol to 24S-OHC is mediated by ch...

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Detalles Bibliográficos
Autores principales: Matsuoka, Hiroshi, Katayama, Miyu, Ohishi, Ami, Miya, Kaoruko, Tokunaga, Riki, Kobayashi, Sou, Nishimoto, Yuya, Hirooka, Kazutake, Shima, Akiho, Michihara, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246805/
https://www.ncbi.nlm.nih.gov/pubmed/32392803
http://dx.doi.org/10.3390/ijms21093309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246805/
https://www.ncbi.nlm.nih.gov/pubmed/32392803
http://dx.doi.org/10.3390/ijms21093309

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