Structural and Evolutionary Analysis Indicate That the SARS-CoV-2 Mpro Is a Challenging Target for Small-Molecule Inhibitor Design

The novel coronavirus whose outbreak took place in December 2019 continues to spread at a rapid rate worldwide. In the absence of an effective vaccine, inhibitor repurposing or de novo drug design may offer a longer-term strategy to combat this and future infections due to similar viruses. Here, we...

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Detalles Bibliográficos
Autores principales: Bzówka, Maria, Mitusińska, Karolina, Raczyńska, Agata, Samol, Aleksandra, Tuszyński, Jack A., Góra, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247150/
https://www.ncbi.nlm.nih.gov/pubmed/32353978
http://dx.doi.org/10.3390/ijms21093099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247150/
https://www.ncbi.nlm.nih.gov/pubmed/32353978
http://dx.doi.org/10.3390/ijms21093099

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