Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin

BACKGROUND: Mithramycin is an anti-tumor compound of the aureolic acid family produced by Streptomyces argillaceus. Its biosynthesis gene cluster has been cloned and characterized, and several new analogs with improved pharmacological properties have been generated through combinatorial biosynthesis...

Descripción completa

Detalles Bibliográficos
Autores principales: Zabala, Daniel, Song, Lijiang, Dashti, Yousef, Challis, Gregory L., Salas, José A., Méndez, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247220/
https://www.ncbi.nlm.nih.gov/pubmed/32448325
http://dx.doi.org/10.1186/s12934-020-01368-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247220/
https://www.ncbi.nlm.nih.gov/pubmed/32448325
http://dx.doi.org/10.1186/s12934-020-01368-3

Ejemplares similares