The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective

Metformin therapy lowers blood glucose in type 2 diabetes by targeting various pathways including hepatic gluconeogenesis. Despite widespread clinical use of metformin the molecular mechanisms by which it inhibits gluconeogenesis either acutely through allosteric and covalent mechanisms or chronical...

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Detalles Bibliográficos
Autores principales: Agius, Loranne, Ford, Brian E., Chachra, Shruti S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247334/
https://www.ncbi.nlm.nih.gov/pubmed/32375255
http://dx.doi.org/10.3390/ijms21093240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247334/
https://www.ncbi.nlm.nih.gov/pubmed/32375255
http://dx.doi.org/10.3390/ijms21093240

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