Cargando…

The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective

Metformin therapy lowers blood glucose in type 2 diabetes by targeting various pathways including hepatic gluconeogenesis. Despite widespread clinical use of metformin the molecular mechanisms by which it inhibits gluconeogenesis either acutely through allosteric and covalent mechanisms or chronical...

Descripción completa

Detalles Bibliográficos
Autores principales:	Agius, Loranne, Ford, Brian E., Chachra, Shruti S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247334/ https://www.ncbi.nlm.nih.gov/pubmed/32375255 http://dx.doi.org/10.3390/ijms21093240

Ejemplares similares

The Protective Role of the Carbohydrate Response Element Binding Protein in the Liver: The Metabolite Perspective
por: Agius, Loranne, et al.
Publicado: (2020)

Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation
por: Moonira, Tabassum, et al.
Publicado: (2020)

Metformin Inhibits Gluconeogenesis by a Redox-Dependent Mechanism In Vivo
por: Madiraju, Anila K., et al.
Publicado: (2018)

Comment on: Stefanovski et al. Estimating Hepatic Glucokinase Activity Using a Simple Model of Lactate Kinetics. Diabetes Care 2012;35:1015–1020
por: Agius, Loranne
Publicado: (2012)

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
por: Madiraju, Anila K., et al.
Publicado: (2014)

The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326
por: Ford, Brian E., et al.
Publicado: (2023)

Mitochondrial Transport in Glycolysis and Gluconeogenesis: Achievements and Perspectives
por: Passarella, Salvatore, et al.
Publicado: (2021)

Role of KLF15 in Regulation of Hepatic Gluconeogenesis and Metformin Action
por: Takashima, Mototsugu, et al.
Publicado: (2010)

Targeting Hepatic Glucokinase in Type 2 Diabetes: Weighing the Benefits and Risks
por: Agius, Loranne
Publicado: (2009)

Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis
por: LaMoia, Traci E., et al.
Publicado: (2022)

The role of AMPK-dependent pathways in cellular and molecular mechanisms of metformin: a new perspective for treatment and prevention of diseases
por: Hasanvand, Amin
Publicado: (2022)

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK
por: Wang, Yu, et al.
Publicado: (2019)

Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms
por: Chen, Suet Ching, et al.
Publicado: (2017)

Phosphoenolpyruvate carboxykinase in cell metabolism: Roles and mechanisms beyond gluconeogenesis
por: Yu, Shuo, et al.
Publicado: (2021)

Protective effects of metformin in various cardiovascular diseases: Clinical evidence and AMPK‐dependent mechanisms
por: Bu, Yizhi, et al.
Publicado: (2022)

The protease SENP2 controls hepatic gluconeogenesis by regulating the SUMOylation of the fuel sensor AMPKα
por: Dou, Xin, et al.
Publicado: (2021)

Metformin regulates myoblast differentiation through an AMPK-dependent mechanism
por: Maniscalco, Eleonora, et al.
Publicado: (2023)

Immunomodulatory and Antiaging Mechanisms of Resveratrol, Rapamycin, and Metformin: Focus on mTOR and AMPK Signaling Networks
por: Sorrenti, Vincenzo, et al.
Publicado: (2022)

Gluconeogenesis in the Yolk Sac Membrane: Enzyme Activity, Gene Expression, and Metabolites During Layer Chicken Development
por: Shibata, Mitsuhiro, et al.
Publicado: (2023)

Neuronal regulation of glucagon secretion and gluconeogenesis
por: Thorens, Bernard
Publicado: (2022)

Empagliflozin Inhibits Hepatic Gluconeogenesis and Increases Glycogen Synthesis by AMPK/CREB/GSK3β Signalling Pathway
por: Yu, Xiaochen, et al.
Publicado: (2022)

Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation
por: Groenendijk, Floris H, et al.
Publicado: (2015)

Cerebral Gluconeogenesis and Diseases
por: Yip, James, et al.
Publicado: (2017)

The molecular mechanism of propionate-regulating gluconeogenesis in bovine hepatocytes
por: Pang, Rui, et al.
Publicado: (2023)

AMPK activators: mechanisms of action and physiological activities
por: Kim, Joungmok, et al.
Publicado: (2016)

Metabolic regulation by the intestinal metformin-AMPK axis
por: Zhang, Song-Yang, et al.
Publicado: (2022)

Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway
por: Cho, Kumsun, et al.
Publicado: (2015)

Metformin selectively dampens the acute inflammatory response through an AMPK-dependent mechanism
por: Postler, Thomas S., et al.
Publicado: (2021)

Expression profile analysis of long non-coding RNAs involved in the metformin-inhibited gluconeogenesis of primary mouse hepatocytes
por: Wang, Yao, et al.
Publicado: (2018)

Measurements of Gluconeogenesis and Glycogenolysis: A Methodological Review
por: Chung, Stephanie T., et al.
Publicado: (2015)

Gluconeogenesis in the kidney: in health and in chronic kidney disease
por: Dalga, Delal, et al.
Publicado: (2023)

Metformin limits osteoarthritis development and progression through activation of AMPK signalling
por: Li, Jun, et al.
Publicado: (2020)

Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal
por: Brynildsen, Julia K., et al.
Publicado: (2018)

Metformin inhibits ALK1-mediated angiogenesis via activation of AMPK
por: Ying, Ying, et al.
Publicado: (2017)

Metformin, an AMPK Activator, Inhibits Activation of FLSs but Promotes HAPLN1 Secretion
por: Chen, Yong, et al.
Publicado: (2020)

Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells
por: Cullen, Kirsty S., et al.
Publicado: (2011)

Effect of reduced energy density of close-up diets on metabolites, lipolysis and gluconeogenesis in Holstein cows
por: Huang, Wenming, et al.
Publicado: (2019)

Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons
por: Bayliss, Jacqueline A., et al.
Publicado: (2016)

The mechanism by which imeglimin inhibits gluconeogenesis in rat liver cells
por: Vial, Guillaume, et al.
Publicado: (2021)

Validation of the Antidiabetic and Hypolipidemic Effects of Clitocybe nuda by Assessment of Glucose Transporter 4 and Gluconeogenesis and AMPK Phosphorylation in Streptozotocin-Induced Mice
por: Shih, Chun-Ching, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_3kfqjdh7ogl50cjjkge7pfdf4o