Cargando…

In silico analysis on the functional and structural impact of Rad50 mutations involved in DNA strand break repair

BACKGROUND: DNA double strand break repair is important to preserve the fidelity of our genetic makeup after DNA damage. Rad50 is one of the components in MRN complex important for DNA repair mechanism. Rad50 mutations can lead to microcephaly, mental retardation and growth retardation in human. How...

Descripción completa

Detalles Bibliográficos
Autores principales:	Remali, Juwairiah, Aizat, Wan Mohd, Ng, Chyan Leong, Lim, Yi Chieh, Mohamed-Hussein, Zeti-Azura, Fazry, Shazrul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2020
Materias:	Bioinformatics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247530/ https://www.ncbi.nlm.nih.gov/pubmed/32509463 http://dx.doi.org/10.7717/peerj.9197

Ejemplares similares

Genomic characterization of a new endophytic Streptomyces kebangsaanensis identifies biosynthetic pathway gene clusters for novel phenazine antibiotic production
por: Remali, Juwairiah, et al.
Publicado: (2017)

Whole-genome shotgun sequence of phenazine-producing endophytic Streptomyces kebangsaanensis SUK12
por: Remali, Juwairiah, et al.
Publicado: (2017)

A Review on Plant Bioactive Compounds and Their Modes of Action Against Coronavirus Infection
por: Remali, Juwairiah, et al.
Publicado: (2021)

Screening of high-risk deleterious missense variations in the CYP1B1 gene implicated in the pathogenesis of primary congenital glaucoma: A comprehensive in silico approach
por: Shahid, Muhammad, et al.
Publicado: (2022)

Xanthone Biosynthetic Pathway in Plants: A Review
por: Remali, Juwairiah, et al.
Publicado: (2022)

Transcriptome analysis of Polygonum minus reveals candidate genes involved in important secondary metabolic pathways of phenylpropanoids and flavonoids
por: Loke, Kok-Keong, et al.
Publicado: (2017)

Cytotoxicity and Toxicity Evaluation of Xanthone Crude Extract on Hypoxic Human Hepatocellular Carcinoma and Zebrafish (Danio rerio) Embryos
por: Fazry, Shazrul, et al.
Publicado: (2018)

Potential Arabidopsis thaliana glucosinolate genes identified from the co-expression modules using graph clustering approach
por: Harun, Sarahani, et al.
Publicado: (2021)

Novel NAD(+)-Farnesal Dehydrogenase from Polygonum minus Leaves. Purification and Characterization of Enzyme in Juvenile Hormone III Biosynthetic Pathway in Plant
por: Seman-Kamarulzaman, Ahmad-Faris, et al.
Publicado: (2016)

Mre11-Rad50 oligomerization promotes DNA double-strand break repair
por: Kissling, Vera M., et al.
Publicado: (2022)

Genetic interactions between INPP4B and RAD50 is prognostic of breast cancer survival
por: Chen, Xiao, et al.
Publicado: (2020)

The role of the Mre11–Rad50–Nbs1 complex in double-strand break repair—facts and myths
por: Takeda, Shunichi, et al.
Publicado: (2016)

DiscoSnp-RAD: de novo detection of small variants for RAD-Seq population genomics
por: Gauthier, Jérémy, et al.
Publicado: (2020)

Adapterama III: Quadruple-indexed, double/triple-enzyme RADseq libraries (2RAD/3RAD)
por: Bayona-Vásquez, Natalia J., et al.
Publicado: (2019)

Homologous recombination repair rathway and RAD54L in early-stage lung adenocarcinoma
por: Zheng, Shaopeng, et al.
Publicado: (2021)

RAD50 Is Required for Efficient Initiation of Resection and Recombinational Repair at Random, γ-Induced Double-Strand Break Ends
por: Westmoreland, Jim, et al.
Publicado: (2009)

Mre11–Rad50–Xrs2 and Sae2 promote 5’ strand resection of DNA double-strand breaks
por: Nicolette, Matthew L., et al.
Publicado: (2010)

Systematic Multi-Omics Integration (MOI) Approach in Plant Systems Biology
por: Jamil, Ili Nadhirah, et al.
Publicado: (2020)

Rad59 regulates association of Rad52 with DNA double-strand breaks
por: Pannunzio, Nicholas R, et al.
Publicado: (2012)

Evaluation of potential molecular interaction between quorum sensing receptor, LuxP and grouper fatty acids: in-silico screening and simulation
por: Low, Chen-Fei, et al.
Publicado: (2019)

Indistinguishable Landscapes of Meiotic DNA Breaks in rad50(+) and rad50S Strains of Fission Yeast Revealed by a Novel rad50(+) Recombination Intermediate
por: Hyppa, Randy W., et al.
Publicado: (2008)

Crystal structure and functional analysis of human C1ORF123
por: A. Rahaman, Siti Nurulnabila, et al.
Publicado: (2018)

Whole genome phylogeny for 21 Drosophila species using predicted 2b-RAD fragments
por: Seetharam, Arun S., et al.
Publicado: (2013)

Characterization of CRISPR RNA transcription by exploiting stranded metatranscriptomic data
por: Ye, Yuzhen, et al.
Publicado: (2016)

OsRAD51C is essential for double-strand break repair in rice meiosis
por: Tang, Ding, et al.
Publicado: (2014)

RAD51 and RAD51B Play Diverse Roles in the Repair of DNA Double Strand Breaks in Physcomitrium patens
por: Angelis, Karel J., et al.
Publicado: (2023)

In-silico study of antisense oligonucleotide antibiotics
por: Chen, Erica S., et al.
Publicado: (2023)

A comparative in-silico analysis of autophagy proteins in ciliates
por: Aslan, Erhan, et al.
Publicado: (2017)

Bridging the TB data gap: in silico extraction of rifampicin-resistant tuberculosis diagnostic test results from whole genome sequence data
por: Ng, Kamela C. S., et al.
Publicado: (2019)

Asf1 facilitates dephosphorylation of Rad53 after DNA double-strand break repair
por: Tsabar, Michael, et al.
Publicado: (2016)

stepRNA: Identification of Dicer cleavage signatures and passenger strand lengths in small RNA sequences
por: Murcott, Ben, et al.
Publicado: (2022)

In silico analyses for potential key genes associated with gastric cancer
por: Yan, Ping, et al.
Publicado: (2018)

In silico discovery of biomarkers for the accurate and sensitive detection of Fusarium solani
por: Bakare, Olalekan Olanrewaju, et al.
Publicado: (2022)

MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex
por: Lee, Kyung Yong, et al.
Publicado: (2015)

In silico identification and in vitro assessment of a potential anti-breast cancer activity of antimicrobial peptide retrieved from the ATMP1 Anabas testudineus fish peptide
por: Law, Douglas, et al.
Publicado: (2023)

In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant KRAS antigens
por: Ng, Allan Wee Ren, et al.
Publicado: (2018)

TODRA, a lncRNA at the RAD51 Locus, Is Oppositely Regulated to RAD51, and Enhances RAD51-Dependent DSB (Double Strand Break) Repair
por: Gazy, Inbal, et al.
Publicado: (2015)

In silico approach to predict pancreatic β-cells classically secreted proteins
por: Pinheiro-Machado, Erika, et al.
Publicado: (2020)

In silico candidate variant and gene identification using inbred mouse strains
por: Munz, Matthias, et al.
Publicado: (2021)

In silico predictions of protein interactions between Zika virus and human host
por: Pitta, João Luiz de Lemos Padilha, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4rdar1bidpk089tcs1dfk15m45