Cargando…

Gene-Wise Burden of Coding Variants Correlates to Noncoding Pharmacogenetic Risk Variants

Genetic variability can modulate individual drug responses. A significant portion of pharmacogenetic variants reside in the noncoding genome yet it is unclear if the noncoding variants directly influence protein function and expression or are present on a haplotype including a functionally relevant...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Jihye, Lee, Soo Youn, Baik, Su Youn, Park, Chan Hee, Yoon, Jun Hee, Ryu, Brian Y., Kim, Ju Han
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247590/ https://www.ncbi.nlm.nih.gov/pubmed/32349395 http://dx.doi.org/10.3390/ijms21093091

Ejemplares similares

Clinical, Pharmacokinetic, and Pharmacogenetic Determinants of Clopidogrel Resistance in Korean Patients with Acute Coronary Syndrome
por: Park, Kyoung-Jin, et al.
Publicado: (2011)

Variant Interpretation in Current Pharmacogenetic Testing
por: Luvsantseren, Sally, et al.
Publicado: (2020)

Star Allele-Based Haplotyping versus Gene-Wise Variant Burden Scoring for Predicting 6-Mercaptopurine Intolerance in Pediatric Acute Lymphoblastic Leukemia Patients
por: Park, Yoomi, et al.
Publicado: (2019)

Step-wise learning of laparoscopic low anterior resection
por: Park, Youn Young, et al.
Publicado: (2021)

Coding and noncoding variants in EBF3 are involved in HADDS and simplex autism
por: Padhi, Evin M., et al.
Publicado: (2021)

Genome Sequence Variability Predicts Drug Precautions and Withdrawals from the Market
por: Lee, Kye Hwa, et al.
Publicado: (2016)

Trimodality therapy in variant urothelial carcinoma: choose wisely
por: Vlachostergios, Panagiotis J., et al.
Publicado: (2017)

Pharmacogenetics implementation in the clinics: information and guidelines for germline variants
por: Olivera, Gladys, et al.
Publicado: (2019)

A SPECTRAL APPROACH INTEGRATING FUNCTIONAL GENOMIC ANNOTATIONS FOR CODING AND NONCODING VARIANTS
por: IONITA-LAZA, IULIANA, et al.
Publicado: (2016)

regBase: whole genome base-wise aggregation and functional prediction for human non-coding regulatory variants
por: Zhang, Shijie, et al.
Publicado: (2019)

Integrating rare genetic variants into pharmacogenetic drug response predictions
por: Ingelman-Sundberg, Magnus, et al.
Publicado: (2018)

An optimized prediction framework to assess the functional impact of pharmacogenetic variants
por: Zhou, Yitian, et al.
Publicado: (2018)

Efficacy of computational predictions of the functional effect of idiosyncratic pharmacogenetic variants
por: McConnell, Hannah, et al.
Publicado: (2021)

Genome-wide burden of deleterious coding variants increased in schizophrenia
por: Loohuis, Loes M. Olde, et al.
Publicado: (2015)

Introme accurately predicts the impact of coding and noncoding variants on gene splicing, with clinical applications
por: Sullivan, Patricia J., et al.
Publicado: (2023)

The association between polymorphism of the long noncoding RNA, Plasmacytoma variant translocation 1, and the risk of gastric cancer
por: Park, Jae Ho, et al.
Publicado: (2021)

GEE: An Informatics Tool for Gene Expression Data Explore
por: Lee, Soo Youn, et al.
Publicado: (2016)

Pharmacogenetic variants of infliximab response in young patients with inflammatory bowel disease
por: Curci, Debora, et al.
Publicado: (2021)

Regulatory Noncoding and Predicted Pathogenic Coding Variants of CCR5 Predispose to Severe COVID-19
por: Cantalupo, Sueva, et al.
Publicado: (2021)

The role of noncoding genetic variants in cardiomyopathy
por: Htet, Myo, et al.
Publicado: (2023)

Fifteen new nucleotide substitutions in variants of human papillomavirus 18 in Korea: Korean HPV18 variants and clinical manifestation
por: Kim, Namhee, et al.
Publicado: (2020)

Identification of pharmacogenetic variants from large scale next generation sequencing data in the Saudi population
por: Goljan, Ewa, et al.
Publicado: (2022)

Total Hip Arthroplasty for Secondary Coxarthrosis in Patients with Hereditary Multiple Exostoses: Minimum 5-Year Follow-up Results and Surgical Considerations
por: Yoon, Jae Youn, et al.
Publicado: (2020)

Functional architecture of low-frequency variants highlights strength of negative selection across coding and noncoding annotations
por: Gazal, Steven, et al.
Publicado: (2018)

Gene-Wise Association of Variants in Four Lysosomal Storage Disorder Genes in Neuropathologically Confirmed Lewy Body Disease
por: Clark, Lorraine N., et al.
Publicado: (2015)

Long Noncoding RNA N-BLR Upregulates the Migration and Invasion of Gastric Adenocarcinoma
por: Youn, Young Hoon, et al.
Publicado: (2019)

Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
por: Qing, Tao, et al.
Publicado: (2020)

DNA-thioguanine nucleotide as a treatment marker in acute lymphoblastic leukemia patients with NUDT15 variant genotypes
por: Ju, Hee Young, et al.
Publicado: (2021)

Pharmacogenetic Study of Deferasirox, an Iron Chelating Agent
por: Lee, Ji Won, et al.
Publicado: (2013)

Long noncoding RNA: noncoding and not coded
por: Toiber, Debra, et al.
Publicado: (2017)

Long noncoding RNA: noncoding and not coded
por: Toiber, Debra, et al.
Publicado: (2017)

Nonhematopoietic Variants of Erythropoietin in Ischemic Stroke: Need for Step-Wise Proof-of-Concept Studies
por: Hermann, Dirk M.
Publicado: (2010)

Analysis of recent shared ancestry in a familial cohort identifies coding and noncoding autism spectrum disorder variants
por: Tuncay, Islam Oguz, et al.
Publicado: (2022)

Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional longevity
por: Gutman, Danielle, et al.
Publicado: (2020)

Pharmacogenetic Associations of MMP9 and MMP12 Variants with Cardiovascular Disease in Patients with Hypertension
por: Tanner, Rikki M., et al.
Publicado: (2011)

Pharmacogenetic variants in TPMT alter cellular responses to cisplatin in inner ear cell lines
por: Bhavsar, Amit P., et al.
Publicado: (2017)

Pharmacogenetic Variants Associated with Fluoxetine Pharmacokinetics from a Bioequivalence Study in Healthy Subjects
por: Díaz-Tufinio, Carlos Alejandro, et al.
Publicado: (2023)

Recommendations for Optimizing Tuberculosis Treatment: Therapeutic Drug Monitoring, Pharmacogenetics, and Nutritional Status Considerations
por: Choi, Rihwa, et al.
Publicado: (2017)

Classic Papillary Thyroid Carcinoma with Tall Cell Features and Tall Cell Variant Have Similar Clinicopathologic Features
por: Oh, Woo Jin, et al.
Publicado: (2014)

Detecting tandem repeat variants in coding regions using code-adVNTR
por: Park, Jonghun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6guh46e05qamn31fecbm0iqeek