Low-Dose Crizotinib, a Tyrosine Kinase Inhibitor, Highly and Specifically Sensitizes P-Glycoprotein-Overexpressing Chemoresistant Cancer Cells Through Induction of Late Apoptosis in vivo and in vitro

We investigated possible conditions or drugs that could target P-glycoprotein (P-gp)-overexpressing drug-resistant KBV20C cancer cells. Specifically, we focused on identifying a single treatment with a relatively low half maximal inhibitory concentration (IC(50)). Our approach utilized repurposing d...

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Detalles Bibliográficos
Autores principales: Kim, Kyeong Seok, Jiang, Chunxue, Kim, Ji Young, Park, Jae Hyeon, Kim, Hae Ri, Lee, Su Hyun, Kim, Hyung Sik, Yoon, Sungpil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247847/
https://www.ncbi.nlm.nih.gov/pubmed/32528877
http://dx.doi.org/10.3389/fonc.2020.00696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247847/
https://www.ncbi.nlm.nih.gov/pubmed/32528877
http://dx.doi.org/10.3389/fonc.2020.00696

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