Cargando…

Low-Dose Crizotinib, a Tyrosine Kinase Inhibitor, Highly and Specifically Sensitizes P-Glycoprotein-Overexpressing Chemoresistant Cancer Cells Through Induction of Late Apoptosis in vivo and in vitro

We investigated possible conditions or drugs that could target P-glycoprotein (P-gp)-overexpressing drug-resistant KBV20C cancer cells. Specifically, we focused on identifying a single treatment with a relatively low half maximal inhibitory concentration (IC(50)). Our approach utilized repurposing d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Kyeong Seok, Jiang, Chunxue, Kim, Ji Young, Park, Jae Hyeon, Kim, Hae Ri, Lee, Su Hyun, Kim, Hyung Sik, Yoon, Sungpil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247847/ https://www.ncbi.nlm.nih.gov/pubmed/32528877 http://dx.doi.org/10.3389/fonc.2020.00696

Ejemplares similares

First-Line Combination Treatment with Low-Dose Bipolar Drugs for ABCB1-Overexpressing Drug-Resistant Cancer Populations
por: Yoon, Sungpil, et al.
Publicado: (2023)

Biological Evaluation of Oxindole Derivative as a Novel Anticancer Agent against Human Kidney Carcinoma Cells
por: Dey, Prasanta, et al.
Publicado: (2020)

Efficacy of crizotinib retreatment after crizotinib-related interstitial lung disease in a patient with ROS1-rearranged advanced lung adenocarcinoma: A case report and potential crizotinib retreatment strategy
por: Ryu, Woo Kyung, et al.
Publicado: (2022)

JAK2 Inhibitor, Fedratinib, Inhibits P-gp Activity and Co-Treatment Induces Cytotoxicity in Antimitotic Drug-Treated P-gp Overexpressing Resistant KBV20C Cancer Cells
por: Oh, Yunmoon, et al.
Publicado: (2022)

Editorial: FDA-Approved Drug Repositioning for P-Glycoprotein Overexpressing Resistant Cancer
por: Yoon, Sungpil, et al.
Publicado: (2021)

Contribution of Cancer-Targeting Drugs toward Faster Clinical Application
por: Yoon, Sungpil, et al.
Publicado: (2022)

A combination of tyrosine kinase inhibitors, crizotinib and dasatinib for the treatment of glioblastoma multiforme
por: Nehoff, Hayley, et al.
Publicado: (2015)

Reactive Oxygen Species (ROS)-Sensitive Prodrugs of the Tyrosine Kinase Inhibitor Crizotinib
por: Bielec, Bjoern, et al.
Publicado: (2020)

Knockdown of Pyruvate Kinase M2 Inhibits Cell Proliferation, Metabolism, and Migration in Renal Cell Carcinoma
por: Dey, Prasanta, et al.
Publicado: (2019)

Ependymomas overexpress chemoresistance and DNA repair-related proteins
por: Ferguson, Sherise D., et al.
Publicado: (2017)

MicroRNAs overexpressed in ovarian ALDH1-positive cells are associated with chemoresistance
por: Park, Young Tae, et al.
Publicado: (2013)

Patients harboring EGFR mutation after primary resistance to crizotinib and response to EGFR-tyrosine kinase inhibitor
por: Wang, Wenxian, et al.
Publicado: (2016)

Lower Salinomycin Concentration Increases Apoptotic Detachment in High-Density Cancer Cells
por: Kim, Ju-Hwa, et al.
Publicado: (2012)

Curcumin Ameliorates Benzo[a]pyrene-Induced DNA Damages in Stomach Tissues of Sprague-Dawley Rats
por: Kim, Kyeong Seok, et al.
Publicado: (2019)

Low-Dose Rifabutin Increases Cytotoxicity in Antimitotic-Drug-Treated Resistant Cancer Cells by Exhibiting Strong P-gp-Inhibitory Activity
por: Lee, Ji Sun, et al.
Publicado: (2022)

Terconazole, an Azole Antifungal Drug, Increases Cytotoxicity in Antimitotic Drug-Treated Resistant Cancer Cells with Substrate-Specific P-gp Inhibitory Activity
por: Lee, Ji Sun, et al.
Publicado: (2022)

Low Amount of Salinomycin Greatly Increases Akt Activation, but Reduces Activated p70S6K Levels
por: Kim, Ju-Hwa, et al.
Publicado: (2013)

siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells
por: Kim, Dae Won, et al.
Publicado: (2009)

Novel Specific Pyruvate Kinase M2 Inhibitor, Compound 3h, Induces Apoptosis and Autophagy through Suppressing Akt/mTOR Signaling Pathway in LNCaP Cells
por: Jiang, Chunxue, et al.
Publicado: (2022)

The effects of crizotinib in a transgenic Drosophila model expressing the human TPM4-ALK fusion gene or TPM4
por: Kim, Yoo Jin, et al.
Publicado: (2019)

HOXB9 Overexpression Confers Chemoresistance to Ovarian Cancer Cells by Inducing ERCC-1, MRP-2, and XIAP
por: Suh, Dong Hoon, et al.
Publicado: (2023)

Glycolytic Metabolic Remodeling by the Truncate of Glioma-Associated Oncogene Homolog 1 in Triple-Negative Breast Cancer Cells
por: Lee, Su Hyun, et al.
Publicado: (2022)

Protective Effects of Dendropanax morbifera against Cisplatin-Induced Nephrotoxicity without Altering Chemotherapeutic Efficacy
por: Kim, Ji Su, et al.
Publicado: (2019)

Epithelial Transfer of the Tyrosine Kinase Inhibitors Erlotinib, Gefitinib, Afatinib, Crizotinib, Sorafenib, Sunitinib, and Dasatinib: Implications for Clinical Resistance
por: Honeywell, Richard J., et al.
Publicado: (2020)

Chemoresistive Sensor Readout Circuit Design for Detecting Gases with Slow Response Time Characteristics
por: Lee, Dong-Yeon, et al.
Publicado: (2022)

Pleiotrophin promotes chemoresistance to doxorubicin in osteosarcoma by upregulating P-glycoprotein
por: Wu, Dapeng, et al.
Publicado: (2017)

Antiulcer Activity of Steamed Ginger Extract against Ethanol/HCl-Induced Gastric Mucosal Injury in Rats
por: Shin, Jun-Kyu, et al.
Publicado: (2020)

DKK3, Downregulated in Invasive Epithelial Ovarian Cancer, Is Associated with Chemoresistance and Enhanced Paclitaxel Susceptibility via Inhibition of the β-Catenin-P-Glycoprotein Signaling Pathway
por: Nguyen, Que Thanh Thanh, et al.
Publicado: (2022)

Disease Flare after Discontinuation of Crizotinib in Anaplastic Lymphoma Kinase-Positive Lung Cancer
por: Kuriyama, Yuka, et al.
Publicado: (2013)

Estrogen Deficiency Potentiates Thioacetamide-Induced Hepatic Fibrosis in Sprague-Dawley Rats
por: Lee, Yong Hee, et al.
Publicado: (2019)

Osteopontin Overexpression Induced Tumor Progression and Chemoresistance to Oxaliplatin through Induction of Stem-Like Properties in Human Colorectal Cancer
por: Ng, Lui, et al.
Publicado: (2015)

P-glycoprotein-mediated chemoresistance is reversed by carbonic anhydrase XII inhibitors
por: Kopecka, Joanna, et al.
Publicado: (2016)

Branebrutinib (BMS-986195), a Bruton’s Tyrosine Kinase Inhibitor, Resensitizes P-Glycoprotein-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Agents
por: Wu, Chung-Pu, et al.
Publicado: (2021)

Dendropanax morbifera Protects against Renal Fibrosis in Streptozotocin-Induced Diabetic Rats
por: Sachan, Richa, et al.
Publicado: (2020)

Overexpression of lung resistance-related protein and P-glycoprotein and response to induction chemotherapy in acute myelogenous leukemia
por: Tsuji, Kazue, et al.
Publicado: (2012)

Tumor evolution and chemoresistance in ovarian cancer
por: Kim, Soochi, et al.
Publicado: (2018)

Crizotinib in advanced non-small-cell lung cancer with concomitant ALK rearrangement and c-Met overexpression
por: Chen, Rui-Lian, et al.
Publicado: (2018)

Crizotinib Exhibits Antitumor Activity by Targeting ALK Signaling not c-MET in Pancreatic Cancer
por: Yan, Hong Hua, et al.
Publicado: (2014)

Anticancer Effects of a New SIRT Inhibitor, MHY2256, against Human Breast Cancer MCF-7 Cells via Regulation of MDM2-p53 Binding
por: Park, Eun Young, et al.
Publicado: (2016)

Overexpression of caveolin-1 attenuates brain edema by inhibiting tight junction degradation
por: Choi, Kang-Ho, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_6tggr47ing4ph16mdl0nhb9rnk