The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes

DNA double-strand breaks (DSBs) are toxic to mammalian cells. However, during meiosis, more than 200 DSBs are generated deliberately, to ensure reciprocal recombination and orderly segregation of homologous chromosomes. If left unrepaired, meiotic DSBs can cause aneuploidy in gametes and compromise...

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Detalles Bibliográficos
Autores principales: ElInati, Elias, Zielinska, Agata P., McCarthy, Afshan, Kubikova, Nada, Maciulyte, Valdone, Mahadevaiah, Shantha, Sangrithi, Mahesh N., Ojarikre, Obah, Wells, Dagan, Niakan, Kathy K., Schuh, Melina, Turner, James M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248069/
https://www.ncbi.nlm.nih.gov/pubmed/32451402
http://dx.doi.org/10.1038/s41467-020-16441-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248069/
https://www.ncbi.nlm.nih.gov/pubmed/32451402
http://dx.doi.org/10.1038/s41467-020-16441-z

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