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Comprehensive analysis of DNA adducts (DNA adductome analysis) in the liver of rats treated with 1,4-dioxane

1,4-Dioxane is a genotoxic carcinogen, and its mutagenic properties were recently observed in the liver of guanine phosphoribosyl transferase (gpt) delta transgenic rats. However, the mechanisms of its genotoxicity remain unclear. We analyzed DNA adduct formation in rat livers following 1,4-dioxane...

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Detalles Bibliográficos
Autores principales: TOTSUKA, Yukari, MAESAKO, Yuya, ONO, Hanako, NAGAI, Momoko, KATO, Mamoru, GI, Min, WANIBUCHI, Hideki, FUKUSHIMA, Shoji, SHIIZAKI, Kazuhiro, NAKAGAMA, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Academy 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248212/
https://www.ncbi.nlm.nih.gov/pubmed/32389918
http://dx.doi.org/10.2183/pjab.96.015