Structure and Characterization of a Covalent Inhibitor of Src Kinase

Unregulated Src activity promotes malignant processes in cancer, but no Src-directed targeted therapies are used clinically, possibly because early Src inhibitors produce off-target effects leading to toxicity. Improved selective Src inhibitors may enable Src-directed therapies. Previously, we repor...

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Detalles Bibliográficos
Autores principales: Gurbani, Deepak, Du, Guangyan, Henning, Nathaniel J., Rao, Suman, Bera, Asim K., Zhang, Tinghu, Gray, Nathanael S., Westover, Kenneth D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248381/
https://www.ncbi.nlm.nih.gov/pubmed/32509799
http://dx.doi.org/10.3389/fmolb.2020.00081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248381/
https://www.ncbi.nlm.nih.gov/pubmed/32509799
http://dx.doi.org/10.3389/fmolb.2020.00081

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