The Jeff Mouse Mutant Model for Chronic Otitis Media Manifests Gain-of-Function as Well as Loss-of-Function Effects

Chronic otitis media (OM) is the most common cause of hearing loss worldwide, yet the underlying genetics and molecular pathology are poorly understood. The mouse mutant Jeff is a single gene mouse model for OM identified from a deafness screen as part of an ENU mutagenesis program at MRC Harwell. J...

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Detalles Bibliográficos
Autores principales: Kubinyecz, Oana, Vikhe, Pratik P., Purnell, Thomas, Brown, Steve D. M., Tateossian, Hilda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248398/
https://www.ncbi.nlm.nih.gov/pubmed/32508883
http://dx.doi.org/10.3389/fgene.2020.00498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248398/
https://www.ncbi.nlm.nih.gov/pubmed/32508883
http://dx.doi.org/10.3389/fgene.2020.00498

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