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Small Molecule Chaperones for the Treatment of Gaucher Disease and GBA1-Associated Parkinson Disease

Parkinson disease, the second most common movement disorder, is a complex neurodegenerative disorder hallmarked by the accumulation of alpha-synuclein, a neural-specific small protein associated with neuronal synapses. Mutations in the glucocerebrosidase gene (GBA1), implicated in the rare, autosoma...

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Detalles Bibliográficos
Autores principales: Han, Tae-Un, Sam, Richard, Sidransky, Ellen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248408/
https://www.ncbi.nlm.nih.gov/pubmed/32509770
http://dx.doi.org/10.3389/fcell.2020.00271