A Pharmacokinetic and Pharmacodynamic Evaluation of the Anti-Hepatocellular Carcinoma Compound 4-N-Carbobenzoxy-gemcitabine (Cbz-dFdC)

Gemcitabine (dFdC) demonstrates significant effectiveness against solid tumors in vitro and in vivo; however, its clinical application is limited because it tends to easily undergo deamination metabolism. Therefore, we synthesized 4-N-carbobenzoxy-gemcitabine (Cbz-dFdC) as a lead prodrug and conduct...

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Detalles Bibliográficos
Autores principales: Sun, Yilin, Wang, Jiankun, Hao, Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248705/
https://www.ncbi.nlm.nih.gov/pubmed/32397338
http://dx.doi.org/10.3390/molecules25092218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248705/
https://www.ncbi.nlm.nih.gov/pubmed/32397338
http://dx.doi.org/10.3390/molecules25092218

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