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Synthesis and Facile Dearomatization of Highly Electrophilic Nitroisoxazolo[4,3-b]pyridines

A number of novel 6-R-isoxazolo[4,3-b]pyridines were synthesized and their reactions with neutral C-nucleophiles (1,3-dicarbonyl compounds, π-excessive (het)arenes, dienes) were studied. The reaction rate was found to be dependent on the nature of the substituent 6-R. The most reactive 6-nitroisoxaz...

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Detalles Bibliográficos
Autores principales: Bastrakov, Maxim A., Fedorenko, Alexey K., Starosotnikov, Alexey M., Fedyanin, Ivan V., Kokorekin, Vladimir A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248838/
https://www.ncbi.nlm.nih.gov/pubmed/32397095
http://dx.doi.org/10.3390/molecules25092194