5-Hydroxyindole-Based EZH2 Inhibitors Assembled via TCCA-Catalyzed Condensation and Nenitzescu Reactions

5-Hydroxyindole derivatives have various demonstrated biological activities. Herein, we used 5-hydroxyindole as a synthetic starting point for structural alterations in a combinatorial process to synthesize 22 different compounds with EZH2 inhibitor pharmacophores. A series of 5-hydroxyindole-derive...

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Detalles Bibliográficos
Autores principales: Du, Fangyu, Zhou, Qifan, Sun, Wenjiao, Yang, Cheng, Wu, Chunfu, Wang, Lihui, Chen, Guoliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248849/
https://www.ncbi.nlm.nih.gov/pubmed/32354194
http://dx.doi.org/10.3390/molecules25092059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248849/
https://www.ncbi.nlm.nih.gov/pubmed/32354194
http://dx.doi.org/10.3390/molecules25092059

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