Preclinical Incorporation Dosimetry of [(18)F]FACH—A Novel (18)F-Labeled MCT1/MCT4 Lactate Transporter Inhibitor for Imaging Cancer Metabolism with PET

Overexpression of monocarboxylate transporters (MCTs) has been shown for a variety of human cancers (e.g., colon, brain, breast, and kidney) and inhibition resulted in intracellular lactate accumulation, acidosis, and cell death. Thus, MCTs are promising targets to investigate tumor cancer metabolis...

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Detalles Bibliográficos
Autores principales: Sattler, Bernhard, Kranz, Mathias, Wenzel, Barbara, Jain, Nalin T., Moldovan, Rareş-Petru, Toussaint, Magali, Deuther-Conrad, Winnie, Ludwig, Friedrich-Alexander, Teodoro, Rodrigo, Sattler, Tatjana, Sadeghzadeh, Masoud, Sabri, Osama, Brust, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248880/
https://www.ncbi.nlm.nih.gov/pubmed/32357571
http://dx.doi.org/10.3390/molecules25092024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248880/
https://www.ncbi.nlm.nih.gov/pubmed/32357571
http://dx.doi.org/10.3390/molecules25092024

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