Rational Design, Synthesis, Characterization and Evaluation of Iodinated 4,4′-Bipyridines as New Transthyretin Fibrillogenesis Inhibitors

The 3,3′,5,5′-tetrachloro-2-iodo-4,4′-bipyridine structure is proposed as a novel chemical scaffold for the design of new transthyretin (TTR) fibrillogenesis inhibitors. In the frame of a proof-of-principle exploration, four chiral 3,3′,5,5′-tetrachloro-2-iodo-2′-substituted-4,4′- bipyridines were r...

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Detalles Bibliográficos
Autores principales: Dessì, Alessandro, Peluso, Paola, Dallocchio, Roberto, Weiss, Robin, Andreotti, Giuseppina, Allocca, Mariateresa, Aubert, Emmanuel, Pale, Patrick, Mamane, Victor, Cossu, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248964/
https://www.ncbi.nlm.nih.gov/pubmed/32397334
http://dx.doi.org/10.3390/molecules25092213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248964/
https://www.ncbi.nlm.nih.gov/pubmed/32397334
http://dx.doi.org/10.3390/molecules25092213

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