Discovery of Novel Pyridazine-Based Cyclooxygenase-2 Inhibitors with a Promising Gastric Safety Profile

Cyclooxygenase-2 (COX-2) is implicated in the development of chronic inflammatory diseases. Recently, pyridazine derivatives have emerged as a novel prototype to develop COX-2 inhibitors. Accordingly, some pyridazine-based COX-2 inhibitors are reported herein. The reaction of aldehyde 3 and differen...

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Detalles Bibliográficos
Autores principales: Khan, Abida, Diwan, Anupama, Thabet, Hamdy Kh., Imran, Mohd, Bakht, Md. Afroz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249006/
https://www.ncbi.nlm.nih.gov/pubmed/32344801
http://dx.doi.org/10.3390/molecules25092002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249006/
https://www.ncbi.nlm.nih.gov/pubmed/32344801
http://dx.doi.org/10.3390/molecules25092002

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