Phenylpyrazalopyrimidines as Tyrosine Kinase Inhibitors: Synthesis, Antiproliferative Activity, and Molecular Simulations

N1-(α,β-Alkene)-substituted phenylpyrazolopyrimidine derivatives with acetyl and functionalized phenyl groups at α- and β-positions, respectively, were synthesized by the reaction of 3-phenylpyrazolopyrimidine (PhPP) with bromoacetone, followed by a chalcone reaction with differently substituted aro...

Descripción completa

Detalles Bibliográficos
Autores principales: Chhikara, Bhupender S., Ashraf, Sajda, Mozaffari, Saghar, St. Jeans, Nicole, Mandal, Dindyal, Tiwari, Rakesh Kumar, Ul-Haq, Zaheer, Parang, Keykavous
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249037/
https://www.ncbi.nlm.nih.gov/pubmed/32370213
http://dx.doi.org/10.3390/molecules25092135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249037/
https://www.ncbi.nlm.nih.gov/pubmed/32370213
http://dx.doi.org/10.3390/molecules25092135

Ejemplares similares