Search for ABCB1 Modulators Among 2-Amine-5-Arylideneimidazolones as a New Perspective to Overcome Cancer Multidrug Resistance

Multidrug resistance (MDR) is a severe problem in the treatment of cancer with overexpression of glycoprotein P (Pgp, ABCB1) as a reason for chemotherapy failure. A series of 14 novel 5-arylideneimidazolone derivatives containing the morpholine moiety, with respect to two different topologies (group...

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Detalles Bibliográficos
Autores principales: Kaczor, Aneta, Nové, Márta, Kincses, Annamária, Spengler, Gabriella, Szymańska, Ewa, Latacz, Gniewomir, Handzlik, Jadwiga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249047/
https://www.ncbi.nlm.nih.gov/pubmed/32403277
http://dx.doi.org/10.3390/molecules25092258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249047/
https://www.ncbi.nlm.nih.gov/pubmed/32403277
http://dx.doi.org/10.3390/molecules25092258

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