Personalized and graph genomes reveal missing signal in epigenomic data

BACKGROUND: Epigenomic studies that use next generation sequencing experiments typically rely on the alignment of reads to a reference sequence. However, because of genetic diversity and the diploid nature of the human genome, we hypothesize that using a generic reference could lead to incorrectly m...

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Detalles Bibliográficos
Autores principales: Groza, Cristian, Kwan, Tony, Soranzo, Nicole, Pastinen, Tomi, Bourque, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249353/
https://www.ncbi.nlm.nih.gov/pubmed/32450900
http://dx.doi.org/10.1186/s13059-020-02038-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249353/
https://www.ncbi.nlm.nih.gov/pubmed/32450900
http://dx.doi.org/10.1186/s13059-020-02038-8

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