CYP and SXR gene polymorphisms influence in opposite ways acute rejection rate in pediatric patients with renal transplant

BACKGROUND: We evaluated the role of CYP3A5, ABCB1 and SXR gene polymorphisms in the occurrence of acute kidney rejection in a cohort of pediatric renal transplant recipients. METHODS: Forty-nine patients were genotyped for CYP3A5, ABCB1 and SXR polymorphisms and evaluated with tacrolimus through le...

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Autores principales: Turolo, Stefano, Edefonti, Alberto, Ghio, Luciana, Testa, Sara, Morello, William, Montini, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249618/
https://www.ncbi.nlm.nih.gov/pubmed/32450827
http://dx.doi.org/10.1186/s12887-020-02152-3
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author Turolo, Stefano
Edefonti, Alberto
Ghio, Luciana
Testa, Sara
Morello, William
Montini, Giovanni
author_facet Turolo, Stefano
Edefonti, Alberto
Ghio, Luciana
Testa, Sara
Morello, William
Montini, Giovanni
author_sort Turolo, Stefano
collection PubMed
description BACKGROUND: We evaluated the role of CYP3A5, ABCB1 and SXR gene polymorphisms in the occurrence of acute kidney rejection in a cohort of pediatric renal transplant recipients. METHODS: Forty-nine patients were genotyped for CYP3A5, ABCB1 and SXR polymorphisms and evaluated with tacrolimus through levels in a retrospective monocenter study. RESULTS: Patients with the A allele of CYP3A5 treated with tacrolimus had a higher risk of acute rejection than those without the A allele, while patients carrying the homozygous GG variant for SXR A7635GG did not show any episode of acute rejection. CONCLUSION: Genetic analysis of polymorphisms implicated in drug metabolism and tacrolimus trough levels may help to forecast the risk of acute rejection and individualize drug dosage in children undergoing renal transplantation.
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spelling pubmed-72496182020-06-04 CYP and SXR gene polymorphisms influence in opposite ways acute rejection rate in pediatric patients with renal transplant Turolo, Stefano Edefonti, Alberto Ghio, Luciana Testa, Sara Morello, William Montini, Giovanni BMC Pediatr Research Article BACKGROUND: We evaluated the role of CYP3A5, ABCB1 and SXR gene polymorphisms in the occurrence of acute kidney rejection in a cohort of pediatric renal transplant recipients. METHODS: Forty-nine patients were genotyped for CYP3A5, ABCB1 and SXR polymorphisms and evaluated with tacrolimus through levels in a retrospective monocenter study. RESULTS: Patients with the A allele of CYP3A5 treated with tacrolimus had a higher risk of acute rejection than those without the A allele, while patients carrying the homozygous GG variant for SXR A7635GG did not show any episode of acute rejection. CONCLUSION: Genetic analysis of polymorphisms implicated in drug metabolism and tacrolimus trough levels may help to forecast the risk of acute rejection and individualize drug dosage in children undergoing renal transplantation. BioMed Central 2020-05-25 /pmc/articles/PMC7249618/ /pubmed/32450827 http://dx.doi.org/10.1186/s12887-020-02152-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Turolo, Stefano
Edefonti, Alberto
Ghio, Luciana
Testa, Sara
Morello, William
Montini, Giovanni
CYP and SXR gene polymorphisms influence in opposite ways acute rejection rate in pediatric patients with renal transplant
title CYP and SXR gene polymorphisms influence in opposite ways acute rejection rate in pediatric patients with renal transplant
title_full CYP and SXR gene polymorphisms influence in opposite ways acute rejection rate in pediatric patients with renal transplant
title_fullStr CYP and SXR gene polymorphisms influence in opposite ways acute rejection rate in pediatric patients with renal transplant
title_full_unstemmed CYP and SXR gene polymorphisms influence in opposite ways acute rejection rate in pediatric patients with renal transplant
title_short CYP and SXR gene polymorphisms influence in opposite ways acute rejection rate in pediatric patients with renal transplant
title_sort cyp and sxr gene polymorphisms influence in opposite ways acute rejection rate in pediatric patients with renal transplant
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249618/
https://www.ncbi.nlm.nih.gov/pubmed/32450827
http://dx.doi.org/10.1186/s12887-020-02152-3
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