Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease

BACKGROUND: Tubulointerstitial fibrosis represents the key underlying pathology of Chronic Kidney Disease (CKD), yet treatment options remain limited. In this study, we investigated the role of connexin43 (Cx43) hemichannel-mediated adenosine triphosphate (ATP) release in purinergic-mediated disasse...

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Detalles Bibliográficos
Autores principales: Price, Gareth W., Chadjichristos, Christos E., Kavvadas, Panagiotis, Tang, Sydney C. W., Yiu, Wai Han, Green, Colin R., Potter, Joe A., Siamantouras, Eleftherios, Squires, Paul E., Hills, Claire E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249671/
https://www.ncbi.nlm.nih.gov/pubmed/32450899
http://dx.doi.org/10.1186/s12964-020-00558-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249671/
https://www.ncbi.nlm.nih.gov/pubmed/32450899
http://dx.doi.org/10.1186/s12964-020-00558-1

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