Hepatic Transcript Profiles of Cytochrome P450 Genes Predict Sex Differences in Drug Metabolism

Safety assessments of new drug candidates are an important part of the drug development and approval process. Often, possible sex-associated susceptibilities are not adequately addressed, and better assessment tools are needed. We hypothesized that hepatic transcript profiles of cytochrome P450 (P45...

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Detalles Bibliográficos
Autores principales: Fuscoe, James C., Vijay, Vikrant, Hanig, Joseph P., Han, Tao, Ren, Lijun, Greenhaw, James J., Beger, Richard D., Pence, Lisa M., Shi, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250365/
https://www.ncbi.nlm.nih.gov/pubmed/32193355
http://dx.doi.org/10.1124/dmd.119.089367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250365/
https://www.ncbi.nlm.nih.gov/pubmed/32193355
http://dx.doi.org/10.1124/dmd.119.089367

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