Molecular characterization of precise in vivo targeted gene integration in human cells using AAVHSC15

Targeted gene integration via precise homologous recombination (HR)-based gene editing has the potential to correct genetic diseases. AAV (adeno-associated virus) can mediate nuclease-free gene integration at a disease-causing locus. Therapeutic application of AAV gene integration requires quantitat...

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Detalles Bibliográficos
Autores principales: Chen, Huei-Mei, Resendes, Rachel, Ghodssi, Azita, Sookiasian, Danielle, Tian, Michael, Dollive, Serena, Adamson-Small, Laura, Avila, Nancy, Tazearslan, Cagdas, Thompson, John F., Ellsworth, Jeff L., Francone, Omar, Seymour, Albert, Wright, Jason B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250422/
https://www.ncbi.nlm.nih.gov/pubmed/32453743
http://dx.doi.org/10.1371/journal.pone.0233373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250422/
https://www.ncbi.nlm.nih.gov/pubmed/32453743
http://dx.doi.org/10.1371/journal.pone.0233373

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