Runx3 prevents spontaneous colitis by directing the differentiation of anti-inflammatory mononuclear phagocytes

Mice deficient in the transcription factor Runx3 develop a multitude of immune system defects, including early onset colitis. This paper demonstrates that Runx3 is expressed in colonic mononuclear phagocytes (MNP), including resident macrophages (RM) and dendritic cell subsets (cDC2). Runx3 deletion...

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Detalles Bibliográficos
Autores principales: Hantisteanu, Shay, Dicken, Yosef, Negreanu, Varda, Goldenberg, Dalia, Brenner, Ori, Leshkowitz, Dena, Lotem, Joseph, Levanon, Ditsa, Groner, Yoram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250423/
https://www.ncbi.nlm.nih.gov/pubmed/32453801
http://dx.doi.org/10.1371/journal.pone.0233044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250423/
https://www.ncbi.nlm.nih.gov/pubmed/32453801
http://dx.doi.org/10.1371/journal.pone.0233044

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