A 3′UTR modification of the TNF-α mouse gene increases peripheral TNF-α and modulates the Alzheimer-like phenotype in 5XFAD mice

Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine, involved in Alzheimer’s disease pathogenesis. Anti-TNF-α therapeutic approaches currently used in autoimmune diseases have been proposed as a therapeutic strategy in AD. We have previously examined the role of TNF-α and anti-TNF-α drugs...

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Detalles Bibliográficos
Autores principales: Kalovyrna, Nikoleta, Apokotou, Olympia, Boulekou, Sotiria, Paouri, Evi, Boutou, Athena, Georgopoulos, Spiros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250826/
https://www.ncbi.nlm.nih.gov/pubmed/32457323
http://dx.doi.org/10.1038/s41598-020-65378-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250826/
https://www.ncbi.nlm.nih.gov/pubmed/32457323
http://dx.doi.org/10.1038/s41598-020-65378-2

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