The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis

DIS3L2-mediated decay (DMD) is a surveillance pathway for certain non-coding RNAs (ncRNAs) including ribosomal RNAs (rRNAs), transfer RNAs (tRNAs), small nuclear RNAs (snRNAs), and RMRP. While mutations in DIS3L2 are associated with Perlman syndrome, the biological significance of impaired DMD is ob...

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Detalles Bibliográficos
Autores principales: Pirouz, Mehdi, Wang, Chih-Hao, Liu, Qi, Ebrahimi, Aref G., Shamsi, Farnaz, Tseng, Yu-Hua, Gregory, Richard I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250864/
https://www.ncbi.nlm.nih.gov/pubmed/32457326
http://dx.doi.org/10.1038/s41467-020-16418-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250864/
https://www.ncbi.nlm.nih.gov/pubmed/32457326
http://dx.doi.org/10.1038/s41467-020-16418-y

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