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The RNA disruption assay is superior to conventional drug sensitivity assays in detecting cytotoxic drugs
Conventional drug sensitivity assays used to screen prospective anti-cancer agents for cytotoxicity monitor biological processes associated with active growth and proliferation, used as proxies of cell viability. However, these assays are unable to distinguish between growth-arrested (but otherwise...
Autores principales: | Mapletoft, Jonathan P. J., St-Onge, Renée J., Guo, Baoqing, Butler, Phillipe, Masilamani, Twinkle J., D’costa, Lavina, Pritzker, Laura B., Parissenti, Amadeo M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250890/ https://www.ncbi.nlm.nih.gov/pubmed/32457334 http://dx.doi.org/10.1038/s41598-020-65579-9 |
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