IDH mutation in glioma: molecular mechanisms and potential therapeutic targets

Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances in cancer genetics over the past decade have revealed that the genes encoding IDHs are frequently mutated in a variety...

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Detalles Bibliográficos
Autores principales: Han, Sue, Liu, Yang, Cai, Sabrina J., Qian, Mingyu, Ding, Jianyi, Larion, Mioara, Gilbert, Mark R., Yang, Chunzhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250901/
https://www.ncbi.nlm.nih.gov/pubmed/32291392
http://dx.doi.org/10.1038/s41416-020-0814-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250901/
https://www.ncbi.nlm.nih.gov/pubmed/32291392
http://dx.doi.org/10.1038/s41416-020-0814-x

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