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P2Y(14) receptor has a critical role in acute gouty arthritis by regulating pyroptosis of macrophages
Nod-like receptor protein 3 (NLRP3)-mediated pyroptosis has a causal role in the pathogenesis of gout. P2Y(14) receptor (P2Y(14)R) distributed in immune cells including macrophages is a Gi-coupled receptor that inhibits the synthesis of cAMP, which has been regarded as a potential regulator of infla...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250907/ https://www.ncbi.nlm.nih.gov/pubmed/32457291 http://dx.doi.org/10.1038/s41419-020-2609-7 |