p190A inactivating mutations cause aberrant RhoA activation and promote malignant transformation via the Hippo-YAP pathway in endometrial cancer

The Rho family of GTPases is strictly regulated by a large family of GTPase-activating proteins (GAPs) that stimulate the relatively weak intrinsic GTP-hydrolyzing activity of Rho GTPases. p190A is a potent and widely expressed GAP that acts on RhoA GTPases. p190A is frequently mutated in endometria...

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Detalles Bibliográficos
Autores principales: Wen, Xiaoli, Wan, Jing, He, Qizhi, Wang, Mengfei, Li, Shuangdi, Jiang, Mei, Qian, Zhen, Liu, Binya, Lu, Wen, Wang, Kai, Gao, Kun, Wan, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250911/
https://www.ncbi.nlm.nih.gov/pubmed/32457342
http://dx.doi.org/10.1038/s41392-020-0170-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250911/
https://www.ncbi.nlm.nih.gov/pubmed/32457342
http://dx.doi.org/10.1038/s41392-020-0170-6

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