A Gilbert syndrome-associated haplotype protects against fatty liver disease in humanized transgenic mice

UDP-glucuronosyltransferases 1 A (UGT1A) enzymes are capable of detoxifying a broad range of endo- and xenobiotic compounds, which contributes to antioxidative effects, modulation of inflammation and cytoprotection. In the presence of low-function genetic UGT1A variants fibrosis development is incre...

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Detalles Bibliográficos
Autores principales: Landerer, Steffen, Kalthoff, Sandra, Paulusch, Stefan, Strassburg, Christian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250928/
https://www.ncbi.nlm.nih.gov/pubmed/32457304
http://dx.doi.org/10.1038/s41598-020-65481-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250928/
https://www.ncbi.nlm.nih.gov/pubmed/32457304
http://dx.doi.org/10.1038/s41598-020-65481-4

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